Medication on long journeys

I have just noticed that when i am a passenger on a long car journey, my impulse to move and the frustration for not being able to move is actually worse when I am medicated, on the last journey I had to ask my wife to stop so i could get out and run around to ease the frustration, I haven’t noticed this in any other setting or maybe i just haven’t noticed because when i am in a situation where i can move around when i want (luckily that is most of the time) then it isn’t a problem, just wondered if anyone else experienced an increase in compulsion to move when medicated or new why it might be.

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